Members run LIUNA, electing officers at all levels and participating in the day-to-day affairs of their Local Unions. Members set priorities for contracts and are the key in the union's growth and success at increasing market share and political strength.

The mission of LIUNA is implemented through nine Regions, more than 40 District Councils, and more than 400 Local Unions. Workers are members of Local Unions. Local Unions work together in District Councils, which are assisted by Regional offices.

Effective May 1, 2023, LIUNA is led by General President Brent Booker, General Secretary-Treasurer Michael F. Sabitoni and the General Executive Board.